Curcumin nanodisk-induced apoptosis in mantle cell lymphoma
نویسندگان
چکیده
منابع مشابه
mantle cell lymphoma 435 APOPTOSIS-RELATED GENES IDENTIFY POOR SURVIVAL GROUP AMONG MANTLE CELL LYMPHOMA PATIENTS
Materials/Method: To examine the relationship between BIM protein expression and genomic BIM loss, we performed Western blotting analysis using whole cell lysates of the seven MCL cell lines. This expression was compared to the results of array CGH, especially for the relationship with BCL2, the antagonist of BIM. In order to understand the relevance of apoptosis-related genes in MCL, published...
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Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node. The gastrointestinal tract is the predominant site of extranodal involvement in the form of multiple lymphomatous polyposis. Multiple lymphomatous polyposis due to mantle cell lymphoma presenting with intussusception is ...
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Mantle cell lymphoma (MCL) generally has an aggressive course with a poor outcome and a median survival of 3–5 years [1]. More than a decade after the hallmark identification of the t(11;14)(q13;32) translocation in MCL, which is the underlying cause of the cell cycle dysregulation and overexpression of cyclin D1, the disease still remains basically incurable with standard combination chemother...
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Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochond...
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Mantle cell lymphoma (MCL) is a well-defined aggressive Non-Hodgkin-lymphoma with short survival rates and remains incurable to date. Previously, we demonstrated the antitumor activity of ZGDHu-1(N, N'-di-(m-methylphenyi)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide) in chronic lymphocytic leukemia. In this study, ZGDHu-1 shows potent anti-lymphoma activity in MCL cells. ZG...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2011
ISSN: 1042-8194,1029-2403
DOI: 10.3109/10428194.2011.584253